ABSTRACT
B Conclusions: b Our findings indicate that intratracheal VSV-CoV2-S peudovirus causes a severe ALI/ARDS in hACE2 transgenic mice, mirroring the reported effects of live SARS-CoV2. B Introduction: b Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in COVID-19. B Methods: b Since rodent ACE2 does not bind to SARS-CoV2 spike protein, K18 human (h) ACE2 transgenic mice were intratracheally inoculated with vesiculovirus harboring the SARS-CoV2 spike protein (VSV-CoV2-S) to induce acute lung injury (ALI, preclinical ARDS). [Extracted from the article] Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)